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Analytical
Ultra­centrifugation

A precise and powerful tool for studying the size and shape of macromolecules in solution

Analytical Ultracentrifugation (AUC) Services

Leverage our extensive AUC experience for precise macromolecular analysis—size, shape, stoichiometry, binding—in a single assay.  

Have additional questions about AUC? Contact us>>

Latest AUC Equipment

Our testing site offers six analytical centrifuges, including Beckman Optima AUCs with improved signal-to-noise, radial resolution, absorbance scanning speed, and superior wavelength selection.

Advanced Technology

Our sedimentation velocity AUC with multi-wavelength analysis ensures the highest resolution and accuracy in testing.

Analytics Portal

Direct access to our experts via a digital platform for quick quoting, sample shipping, project status tracking, and results access.

Expertise

Our team comprises industry-recognized AUC experts with over 20 years of experience and numerous publications in AUC applications.

Diverse Molecule Experience

Our expert team has completed hundreds of AUC projects on proteins, peptides, nucleic acids, viruses, and other macromolecules.

Regulatory Compliance

Our AUC services are fully validated within GMP environment and seamlessly integrated with release testing requirements.

 

Our testing site offers six analytical centrifuges, including Beckman Optima AUCs with improved signal-to-noise, radial resolution, absorbance scanning speed, and superior wavelength selection.
Our sedimentation velocity AUC with multi-wavelength analysis ensures the highest resolution and accuracy in testing.
Direct access to our experts via a digital platform for quick quoting, sample shipping, project status tracking, and results access.
Our team comprises industry-recognized AUC experts with over 20 years of experience and numerous publications in AUC applications.
Our expert team has completed hundreds of AUC projects on proteins, peptides, nucleic acids, viruses, and other macromolecules.
Our AUC services are fully validated within GMP environment and seamlessly integrated with release testing requirements.
Have additional questions about AUC? Contact us>>

Ready to Get Started with AUC?

Use the KBI Biopharma Analytics Portal for quick access to quoting, service ordering, sample shipping, and progress tracking.

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Explore Recent Resources

KBI_VirusFillStates_Parent3
Article

Adeno-Associated Virus-Mediated Gene Therapy: Analytical Advancements in Characterizing Size Distribution using SV-AUC and Multi-Wavelength Analysis for Accurate Identification of Resolved Species

At KBI Biopharma, we are leading the way in fully characterizing the size distribution of AAV products using SV-AUC combined with multi-wavelength analysis, giving us the ability to accurately identify each resolved species. 

KBI_VirusFillStates_v2b
Poster

Characterization and Quantification of Adeno-associated Virus Fill States Using Analytical Ultracentrifugation

In this poster, we show how this analysis can be used to identify empty, partially-packaged and full capsids, calculate the ratio of protein to DNA present in well resolved species, and compare the multi-wavelength results with expected values that arise from a consideration of the shape properties of AAVs. Furthermore, we show how this approach can help eliminate false peak identification. 

KBI_VirusFillStates_v2a
Poster

Comprehensive Size Distribution Analysis of Adeno-Associated Virus Fill States

In this poster, we compare the results from SV-AUC with MWA with two orthogonal separation methods: sedimentation equilibrium (SE) CsCl density gradient analysis and size exclusion chromatography coupled with multiple angle light scattering (SEC-MALS).

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