Cell Line Development

Engineering New Biologics, At Scale

Making Complex Applications Possible with Mammalian-Based and Microbial-Based Expression for New Biologics

With a solid foundation in analytics combined with our best-in-class cell line development (CLD) platform, KBI provides efficiently integrated services for First in Human (FIH) programs from CLD through to commercial manufacturing.

KBI's cell line development activities are performed as standalone services or fully integrated into larger process development programs to support projects from CLD through to clinical or commercial manufacturing in our cGMP facilities.

Mammalian Cell Line Development 

Leveraging advanced gene technology and a proprietary gold standard cell line to meet the challenges of cell line development (CLD) for unique and innovative biologics.

At KBI Biopharma, as a global partner for mammalian-based biopharmaceutical development, we have engineered the standard Chinese Hamster Ovary (CHO) workhorse to create our premium cell line for mammalian-based expression. 

Learn More: Mammalian Cell Line Development

Microbial Cell Line Development 

KBI uses an early optimization workflow to ensure manufacturing success. As a result, more molecules are manufactured using an E. Coli expression system than ever before.

Ahead of upstream process development, KBI focuses on microfermentation screening for microbial cell line development (CLD) to yield consistent, high titers across strains and molecules. At KBI, our years of vertical process integration knowledge and data can allow us to scale directly into 10L stainless steel or 30L single-use systems.

Learn More: Microbial Cell Line Development

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